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Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm

Phosphatidylserine (PS) exposure on the external leaflet of the plasma membrane is widely observed during apoptosis and forms the basis for the annexin V binding assay to detect apoptotic cell death. Current efforts to explain PS exposure focus on two potential mechanisms, activation of a phospholip...

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Detalhes bibliográficos
Main Authors: Lee, S-H, Meng, X W, Flatten, K S, Loegering, D A, Kaufmann, S H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524639/
https://ncbi.nlm.nih.gov/pubmed/22858544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.93
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