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Multi-armed cationic cyclodextrin:poly(ethylene glycol) polyrotaxanes as efficient gene silencing vectors()

A family of branched polyrotaxanes (bPRTx(+)), threaded with multiple cationic α-cyclodextrins (α-CDs) onto a multi-armed poly(ethylene glycol) (PEG) core, were synthesized and studied as gene silencing vectors. These bPRTx(+) formed stable, positively charged complexes with diameters of 150–250 nm...

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Main Authors: Kulkarni, Aditya, DeFrees, Kyle, Schuldt, Ryan A., Vlahu, Alexander, VerHeul, Ross, Hyun, Seok-Hee, Deng, Wei, Thompson, David H.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524380/
https://ncbi.nlm.nih.gov/pubmed/23042106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ib20107k
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