Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study

Imputation has been widely used in genome-wide association studies (GWAS) to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships...

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Detalhes bibliográficos
Main Authors: Chen, Ming-Huei, Huang, Jie, Chen, Wei-Min, Larson, Martin G., Fox, Caroline S., Vasan, Ramachandran S., Seshadri, Sudha, O’Donnell, Christopher J., Yang, Qiong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524237/
https://ncbi.nlm.nih.gov/pubmed/23284720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051589
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