Collaboration Between Macrophages and Vaccine-Induced CD4(+) T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia

The usefulness of vaccine-based strategies to prevent lethal bacterial infection in a host with neutropenia is not well-defined. Here, we show in a neutropenic mouse model that immunity induced by mucosal vaccination with a live-attenuated Pseudomonas aeruginosa vaccine is protective against lethal...

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Detalhes bibliográficos
Main Authors: Kamei, Akinobu, Wu, Weihui, Traficante, David C., Koh, Andrew Y., Van Rooijen, Nico, Pier, Gerald B., Priebe, Gregory P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523801/
https://ncbi.nlm.nih.gov/pubmed/23100569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis657
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