MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer

Ubiquitin-specific protease 2a (USP2a) is overexpressed in almost half of human prostate cancers and c-Myc is amplified in one third of these tumor types. Transgenic MYC expression drives invasive adenocarcinomas in the murine prostate. We show that overexpression of USP2a downregulates a set of mic...

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Autors principals: Benassi, Barbara, Flavin, Richard, Marchionni, Luigi, Zanata, Silvio, Pan, Yunfeng, Chowdhury, Dipanjan, Marani, Marina, Strano, Sabrina, Muti, Paola, Blandino, Giovanni, Loda, Massimo
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523361/
https://ncbi.nlm.nih.gov/pubmed/22585994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0219
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