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TRPM8 Ion Channels Differentially Modulate Proliferation and Cell Cycle Distribution of Normal and Cancer Prostate Cells

Overexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific blockers, AMTB and JNJ41876666, and RNAi to determ...

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Bibliografski detalji
Glavni autori: Valero, María Ll., Mello de Queiroz, Fernanda, Stühmer, Walter, Viana, Félix, Pardo, Luis A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522609/
https://ncbi.nlm.nih.gov/pubmed/23251635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051825
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