TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipidinduced inflammation and insulin resistance in muscle cells

Emerging evidence suggests that TLR (Toll-like receptor) 4 and downstream pathways [MAPKs (mitogen-activated protein kinases) and NF-κB (nuclear factor κB)] play an important role in the pathogenesis of insulin resistance. LPS (lipopolysaccharide) and saturated NEFA (non-esterified fatty acids) acti...

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Main Authors: Hussey, Sophie E., Liang, Hanyu, Costford, Sheila R., Klip, Amira, DeFronzo, Ralph A., Sanchez-Avila, Alicia, Ely, Brian, Musi, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2012
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522475/
https://ncbi.nlm.nih.gov/pubmed/23050932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120098
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