Use of High-Pressure Liquid Chromatography to Determine Plasma Levels of Metronidazole and Metabolites After Intravenous Administration

A rapid and sensitive high-pressure liquid chromatography assay for metronidazole and its two principle metabolites, 1-(2-hydroxyethyl-2-hydroxymethyl)-5-nitro-imidazole [hydroxy metabolite] and 1-acetic acid-2-methyl-5-metronidazole [acid metabolite], was developed. The retention times observed wer...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Wheeler, L. A., De Meo, M., Halula, M., George, L., Heseltine, P.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1978
Subjects:	Pharmacology and Therapeutics
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352215/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/646342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.13.2.205
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