Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent

Chromosomal DNA must be in single-strand form for important transactions such as replication, transcription, and recombination to occur. The single-strand DNA (ssDNA) is more prone to damage than double-strand DNA (dsDNA), due to greater exposure of chemically reactive moieties in the nitrogenous ba...

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Bibliografiska uppgifter
Huvudupphovsmän: Chan, Kin, Sterling, Joan F., Roberts, Steven A., Bhagwat, Ashok S., Resnick, Michael A., Gordenin, Dmitry A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521656/
https://ncbi.nlm.nih.gov/pubmed/23271983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003149
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