The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres

The INO80 chromatin remodeling complex functions in transcriptional regulation, DNA repair, and replication. Here we uncover a novel role for INO80 in regulating chromosome segregation. First, we show that the conserved Ies6 subunit is critical for INO80 function in vivo. Strikingly, we found that l...

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Detalhes bibliográficos
Main Authors: Chambers, Anna L., Ormerod, Georgina, Durley, Samuel C., Sing, Tina L., Brown, Grant W., Kent, Nicholas A., Downs, Jessica A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521627/
https://ncbi.nlm.nih.gov/pubmed/23207916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.199976.112
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