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Leptin regulates cyclin D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumors
PURPOSE: Leptin, an adipose secreted cytokine, is implicated in mammary cancer stem cell self-renewal and tumor growth in Murine Mammary Tumor Virus (MMTV)-Wnt-1 transgenic mice. In vitro studies indicate that leptin induces expression of Cyclin D1, a cell-cycle control protein necessary for mammary...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3520612/ https://ncbi.nlm.nih.gov/pubmed/22692856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-012-1252-9 |
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