FTY720 Markedly Increases Alloengraftment But Does Not Eliminate Host Anti-Donor T Cells That Cause Graft Rejection Upon Its Withdrawal

The immunomodulator FTY720 (FTY) is beneficial in models of graft-versus-host disease, solid organ transplantation, and autoimmunity and has been approved for use in multiple sclerosis patients. FTY modifies the homing and migration of many cell types. We now show that FTY has profound positive and...

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Autors principals: Taylor, Patricia A., Kelly, Ryan M., Bade, Nick D., Smith, Michelle J., Stefanski, Heather E., Blazar, Bruce R.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520609/
https://ncbi.nlm.nih.gov/pubmed/22728248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2012.06.007
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