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Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines

The asymmetric synthesis of new chiral γ-chloro-α,β-diaminocarboxylamide derivatives by highly diastereoselective Mannich-type reactions of N-(diphenylmethylene)glycinamides across chiral α-chloro-N-p-toluenesulfinylaldimines was developed. The resulting (S(S),2S,3S)-γ-chloro-α,β-diaminocarboxylamid...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Callebaut, Gert, Mangelinckx, Sven, Van der Veken, Pieter, Törnroos, Karl W, Augustyns, Koen, De Kimpe, Norbert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Beilstein-Institut 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520569/
https://ncbi.nlm.nih.gov/pubmed/23243474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.8.239
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