Robust Suppression of HIV Replication by Intracellularly Expressed Reverse Transcriptase Aptamers Is Independent of Ribozyme Processing

RNA aptamers that bind human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT) also inhibit viral replication, making them attractive as therapeutic candidates and potential tools for dissecting viral pathogenesis. However, it is not well understood how aptamer-expression context and cellu...

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Bibliografiske detaljer
Main Authors: Lange, Margaret J, Sharma, Tarun K, Whatley, Angela S, Landon, Linda A, Tempesta, Michael A, Johnson, Marc C, Burke, Donald H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519987/
https://ncbi.nlm.nih.gov/pubmed/22948672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.158
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