Escherichia coli–expressed near full length HIV-1 envelope glycoprotein is a highly sensitive and specific diagnostic antigen

BACKGROUND: The Human Immunodeficiency Virus type 1 (HIV-1) envelope glycoprotein gp160, useful in detecting anti-HIV-1 antibodies, is difficult to express in heterologous hosts. The major hurdles are its signal sequence, strong hydrophobic regions and heavy glycosylation. While it has not been poss...

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Detalhes bibliográficos
Main Authors: Talha, Sheikh M, Nemani, Satish Kumar, Salminen, Teppo, Kumar, Sushil, Swaminathan, Sathyamangalam, Soukka, Tero, Pettersson, Kim, Khanna, Navin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519745/
https://ncbi.nlm.nih.gov/pubmed/23186021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-12-325
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