The oncoprotein and stem cell renewal factor BMI1 associates with poor clinical outcome in oesophageal cancer patients undergoing preoperative chemoradiotherapy

BACKGROUND: The polycomb group (PcG) family BMI1, acting downstream of the hedgehog (Hh) pathway, plays an essential role in the self-renewal of haematopoietic, neural, and intestinal stem cells, and is dysregulated in many types of cancer. Our recent report has demonstrated that Hh signalling activ...

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Autores principales: Yoshikawa, Reigetsu, Tsujimura, Tohru, Tao, Lihua, Kamikonya, Norihiko, Fujiwara, Yoshinori
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519675/
https://ncbi.nlm.nih.gov/pubmed/23046527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-461
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