A Natural Variant of Obestatin, Q90L, Inhibits Ghrelin's Action on Food Intake and GH Secretion and Targets NPY and GHRH Neurons in Mice

BACKGROUND: Ghrelin and obestatin are two gut-derived peptides originating from the same ghrelin/obestatin prepropeptide gene (GHRL). While ghrelin stimulates growth hormone (GH) secretion and food intake and inhibits γ-aminobutyric-acid synaptic transmission onto GHRH (Growth Hormone Releasing Horm...

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Hauptverfasser: Hassouna, Rim, Zizzari, Philippe, Viltart, Odile, Yang, Seung-Kwon, Gardette, Robert, Videau, Catherine, Badoer, Emilio, Epelbaum, Jacques, Tolle, Virginie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519497/
https://ncbi.nlm.nih.gov/pubmed/23251435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051135
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