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Olorin: combining gene flow with exome sequencing in large family studies of complex disease
Motivation: The existence of families with many individuals affected by the same complex disease has long suggested the possibility of rare alleles of high penetrance. In contrast to Mendelian diseases, however, linkage studies have identified very few reproducibly linked loci in diseases such as di...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3519455/ https://ncbi.nlm.nih.gov/pubmed/23052039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bts609 |
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