A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma

BACKGROUND: We propose a two-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma. METHODS: First, we fit segregation models by formulating the likeliho...

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Autori principali: Sun, Xiangqing, Vengoechea, Jaime, Elston, Robert, Chen, Yanwen, Amos, Christopher I., Armstrong, Georgina, Bernstein, Jonine L, Claus, Elizabeth, Davis, Faith, Houlston, Richard S, Il'yasova, Dora, Jenkins, Robert B, Johansen, Christoffer, Lai, Rose, Lau, Ching C, Liu, Yanhong, McCarthy, Bridget J, Olson, Sara H, Sadetzki, Siegal, Schildkraut, Joellen, Shete, Sanjay, Yu, Robert, Vick, Nicholas A, Merrell, Ryan, Wrensch, Margaret, Yang, Ping, Melin, Beatrice, Bondy, Melissa L., Barnholtz-Sloan, Jill S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518573/
https://ncbi.nlm.nih.gov/pubmed/22962404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-12-0703
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