Harnessing the unique local immunostimulatory properties of modified vaccinia Ankara (MVA) virus to generate superior tumor-specific immune responses and antitumor activity in a diversified prime-and-boost vaccine regimen

Recombinant poxviruses expressing tumor-associated antigens (TAA) are currently being evaluated in clinical trials as an approach to treat various cancers. We have previously generated poxviral vectors expressing a TAA and a TRiad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; TRICOM) as trans...

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Bibliographic Details
Main Authors: Hodge, James W., Higgins, Jack, Schlom, Jeffrey
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518379/
https://ncbi.nlm.nih.gov/pubmed/19450631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.05.017
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