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Harnessing the unique local immunostimulatory properties of modified vaccinia Ankara (MVA) virus to generate superior tumor-specific immune responses and antitumor activity in a diversified prime-and-boost vaccine regimen
Recombinant poxviruses expressing tumor-associated antigens (TAA) are currently being evaluated in clinical trials as an approach to treat various cancers. We have previously generated poxviral vectors expressing a TAA and a TRiad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; TRICOM) as trans...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518379/ https://ncbi.nlm.nih.gov/pubmed/19450631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.05.017 |
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