Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231

BACKGROUND: Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) are both expressed by a number of malignant tumors, including those of the breast. In the latter, both behave as potent inhibitors of invasion. Nevertheless, the signaling pathways whereby the activated GnRH/GnRHR system exer...

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Main Authors: Aguilar-Rojas, Arturo, Huerta-Reyes, Maira, Maya-Núñez, Guadalupe, Arechavaleta-Velásco, Fabián, Conn, P Michael, Ulloa-Aguirre, Alfredo, Valdés, Jesús
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518142/
https://ncbi.nlm.nih.gov/pubmed/23176180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-550
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