Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors

Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The EPR effect (Enhanced Permeability and Retention) can permit passive accumulation into tumor interstitium. However, suboptimal delivery is achieved with...

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Hauptverfasser: Manzoor, Ashley A., Lindner, Lars H., Landon, Chelsea D., Park, Ji-Young, Simnick, Andrew J., Dreher, Matthew R., Das, Shiva, Hanna, Gabi, Park, Won, Chilkoti, Ashutosh, Koning, Gerben A., Hagen, Timo L.M. ten, Needham, David, Dewhirst, Mark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517817/
https://ncbi.nlm.nih.gov/pubmed/22952218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1683
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