Sequential expression of IGF-IB followed by active TGF-β1 induces synergistic pulmonary fibroproliferation in vivo

Pulmonary fibrosis, the end stage of a variety of fibroproliferative lung diseases, is usually induced after repetitive or chronic lung injury or inflammation. The mechanisms of fibroproliferation are poorly understood. Insulin-like growth factor-I (IGF-I) is significantly elevated in patients with...

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Main Authors: Andonegui, Graciela, Ni, Ai, Léger, Caroline, Kelly, Margaret M., Wong, Josée F., Jalloul, Ali, Winston, Brent W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517679/
https://ncbi.nlm.nih.gov/pubmed/22923639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00008.2012
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