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Renal cortical hemopexin accumulation in response to acute kidney injury

Hemopexin (Hpx) is a liver-generated acute phase reactant that binds and neutralizes prooxidant free heme. This study tested whether acute kidney injury (AKI) triggers renal Hpx accumulation, potentially impacting heme Fe-mediated tubular injury. Mice were subjected to glycerol, cisplatin, ischemia-...

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Bibliographic Details
Main Authors: Zager, Richard A., Johnson, Ali C. M., Becker, Kirsten
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517628/
https://ncbi.nlm.nih.gov/pubmed/22993068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00426.2012
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