Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

BACKGROUND: Spinal glia, particularly microglia and astrocytes, are of the utmost importance in the development and maintenance of chronic pain. A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently...

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Main Authors: Yang, Jia-Le, Xu, Bo, Li, Shuang-Shuang, Zhang, Wei-Shi, Xu, Hua, Deng, Xiao-Ming, Zhang, Yu-Qiu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517515/
https://ncbi.nlm.nih.gov/pubmed/22647647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-5-18
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