Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

BACKGROUND: Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases. Breast cancer cell models reveal that endocrine resistance is accompanied by a gain in aggressive behavi...

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Autores principales: Hiscox, Stephen, Baruha, Bedanta, Smith, Chris, Bellerby, Rebecca, Goddard, Lindy, Jordan, Nicola, Poghosyan, Zaruhi, Nicholson, Robert I, Barrett-Lee, Peter, Gee, Julia
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517483/
https://ncbi.nlm.nih.gov/pubmed/23039365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-458
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