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Structural Study-Guided Development of Versatile Phase Transfer Catalysts for Asymmetric Conjugate Additions of Cyanide

New phase transfer catalysts are reported for the first example of an organocatalytic asymmetric conjugate addition of cyanide with acetone cyanohydrin. Utilizing an accessible cupreidinium salt and a cyanation reagent suitable for industrial scale, this reaction holds significant promise for practi...

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Detalhes bibliográficos
Main Authors: Provencher, Brian A., Bartelson, Keith J., Liu, Yan, Foxman, Bruce M., Deng, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517059/
https://ncbi.nlm.nih.gov/pubmed/21919177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201105536
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