APOE and A-betaPP Gene Variation in Cortical and Cerebrovascular Amyloid-beta Pathology and Alzheimer’s Disease: A Population-Based Analysis

Cortical and cerebrovascular amyloid-beta (A-beta) deposition is a hallmark of Alzheimer’s disease (AD), but also occurs in elderly people not affected by dementia. The apolipoprotein E (APOE) epsilon4 is a major genetic modulator of A-beta deposition and AD risk. Variants of the amyloid-beta protei...

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Autori principali: Peuralinna, Terhi, Tanskanen, Maarit, Mäkelä, Mira, Polvikoski, Tuomo, Paetau, Anders, Kalimo, Hannu, Sulkava, Raimo, Hardy, John, Lai, Shiao-Lin, Arepalli, Sampath, Hernandez, Dena, Traynor, Bryan J., Singleton, Andrew, Tienari, Pentti J., Myllykangas, Liisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516850/
https://ncbi.nlm.nih.gov/pubmed/21654062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-102049
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