Transient Activation of the PI3K-AKT Pathway by Hepatitis C Virus to Enhance Viral Entry

The PI3K-AKT signaling pathway plays an important role in cell growth and metabolism. Here we report that hepatitis C virus (HCV) transiently activates the PI3K-AKT pathway. This activation was observed as early as 15 min postinfection, peaked by 30 min, and became undetectable at 24 h postinfection...

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Bibliografiske detaljer
Main Authors: Liu, Zhe, Tian, Yongjun, Machida, Keigo, Lai, Michael M. C., Luo, Guangxiang, Foung, Steven K. H., Ou, Jing-hsiung James
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516739/
https://ncbi.nlm.nih.gov/pubmed/23095753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414789
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