Ciliary Neurotrophic Factor Protects Mice Against Streptozotocin-induced Type 1 Diabetes through SOCS3: THE ROLE OF STAT1/STAT3 RATIO IN β-CELL DEATH

Type 1 diabetes is characterized by a loss of islet β-cells. Ciliary neurotrophic factor (CNTF) protects pancreatic islets against cytokine-induced apoptosis. For this reason, we assessed whether CNTF protects mice against streptozotocin-induced diabetes (a model of type 1 diabetes) and the mechanis...

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Detalhes bibliográficos
Main Authors: Rezende, Luiz F., Santos, Gustavo J., Carneiro, Everardo M., Boschero, Antonio C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516714/
https://ncbi.nlm.nih.gov/pubmed/23038263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358788
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