Attenuated Salmonella Typhimurium Lacking the Pathogenicity Island-2 Type 3 Secretion System Grow to High Bacterial Numbers inside Phagocytes in Mice

Intracellular replication within specialized vacuoles and cell-to-cell spread in the tissue are essential for the virulence of Salmonella enterica. By observing infection dynamics at the single-cell level in vivo, we have discovered that the Salmonella pathogenicity island 2 (SPI-2) type 3 secretory...

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Detalhes bibliográficos
Main Authors: Grant, Andrew J., Morgan, Fiona J. E., McKinley, Trevelyan J., Foster, Gemma L., Maskell, Duncan J., Mastroeni, Pietro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516571/
https://ncbi.nlm.nih.gov/pubmed/23236281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003070
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