Anti-Glucocorticoid Gene Therapy Reverses the Impairing Effects of Elevated Corticosterone on Spatial Memory, Hippocampal Neuronal Excitability, and Synaptic Plasticity

Moderate release of the major stress hormones, glucocorticoids (GCs), improves hippocampal function and memory. In contrast, excessive or prolonged elevations produce impairments. Enzymatic degradation and reformation of GCs help to maintain optimal levels within target tissues, including the brain....

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Detalhes bibliográficos
Main Authors: Dumas, Theodore C., Gillette, Todd, Ferguson, Deveroux, Hamilton, Kelly, Sapolsky, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516494/
https://ncbi.nlm.nih.gov/pubmed/20130180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4402-09.2010
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