JAK kinases are required for the bacterial RNA and poly I:C induced tyrosine phosphorylation of PKR

Discriminating the molecular patterns associated with RNA is central to innate immunity. The protein kinase PKR is a cytosolic sensor involved in the recognition of viral dsRNA and triggering interferon-induced signaling. Here, we identified bacterial RNA as a novel distinct pattern recognized by PK...

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Detalhes bibliográficos
Main Authors: Bleiblo, Farag, Michael, Paul, Brabant, Danielle, Ramana, Chilakamarti V, Tai, TC, Saleh, Mazen, Parrillo, Joseph E, Kumar, Anand, Kumar, Aseem
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515974/
https://ncbi.nlm.nih.gov/pubmed/23236554
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