CpG islands and GC content dictate nucleosome depletion in a transcription-independent manner at mammalian promoters

One clear hallmark of mammalian promoters is the presence of CpG islands (CGIs) at more than two-thirds of genes, whereas TATA boxes are only present at a minority of promoters. Using genome-wide approaches, we show that GC content and CGIs are major promoter elements in mammalian cells, able to gov...

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Bibliografiske detaljer
Main Authors: Fenouil, Romain, Cauchy, Pierre, Koch, Frederic, Descostes, Nicolas, Cabeza, Joaquin Zacarias, Innocenti, Charlène, Ferrier, Pierre, Spicuglia, Salvatore, Gut, Marta, Gut, Ivo, Andrau, Jean-Christophe
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514669/
https://ncbi.nlm.nih.gov/pubmed/23100115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.138776.112
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