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A Small Molecule Inhibitor of Pot1 Binding to Telomeric DNA
Chromosome ends are complex structures, consisting of repetitive DNA sequence terminating in an ssDNA overhang with many associated proteins. Because alteration of these ends is a hallmark of cancer, telomeres and telomere maintenance have been prime drug targets. The universally conserved ssDNA ove...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3514547/ https://ncbi.nlm.nih.gov/pubmed/22978652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300365k |
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