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A Small Molecule Inhibitor of Pot1 Binding to Telomeric DNA

Chromosome ends are complex structures, consisting of repetitive DNA sequence terminating in an ssDNA overhang with many associated proteins. Because alteration of these ends is a hallmark of cancer, telomeres and telomere maintenance have been prime drug targets. The universally conserved ssDNA ove...

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Sonraí Bibleagrafaíochta
Main Authors: Altschuler, Sarah E., Croy, Johnny E., Wuttke, Deborah S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514547/
https://ncbi.nlm.nih.gov/pubmed/22978652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300365k
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