Knockout of the 15 kDa Selenoprotein Protects against Chemically-Induced Aberrant Crypt Formation in Mice

Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells resulted in the reversal of the cancer phenotype. T...

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Main Authors: Tsuji, Petra A., Carlson, Bradley A., Naranjo-Suarez, Salvador, Yoo, Min-Hyuk, Xu, Xue-Ming, Fomenko, Dmitri E., Gladyshev, Vadim N., Hatfield, Dolph L., Davis, Cindy D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514276/
https://ncbi.nlm.nih.gov/pubmed/23226526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050574
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