Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells

Ezrin is a multifunctional protein that connects the actin cytoskeleton to the extracellular matrix through transmembrane proteins. High ezrin expression is associated with lung metastasis and poor survival in cancer. We screened small molecule libraries for compounds that directly interact with ezr...

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Bibliografiske detaljer
Main Authors: Bulut, G, Hong, S-H, Chen, K, Beauchamp, EM, Rahim, S, Kosturko, GW, Glasgow, E, Dakshanamurthy, S, Lee, H-S, Daar, I, Toretsky, JA, Khanna, C, Üren, A
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513970/
https://ncbi.nlm.nih.gov/pubmed/21706056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.245
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