Role of thymus for N-acetyl muramyl-L-alanyl-D-isoglutamine-induced polyarthritis and granuloma formation in euthymic and athymic nude rats or in neonatally thymectomized rats.

A synthetic adjuvant, N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP), produced extremely severe polyarthritis with almost 100% incidence in Rowett euthymic rnu/+ rats, but the same dose of MDP (100 microgram) did not produce the disease in athymic rnu/rnu rats. Five hundred micrograms of MDP or 0.2...

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Detalhes bibliográficos
Main Authors: Kohashi, O, Pearson, C M, Tamaoki, N, Tanaka, A, Shimamura, K, Ozawa, A, Kotani, S, Saito, M, Hioki, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1981
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC351375/
https://ncbi.nlm.nih.gov/pubmed/7012019
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