Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes

FIV establishes a latent infection in peripheral CD4+ T-cells, and the latent FIV promoter is associated with deacetylated, methylated histones, consistent with a restrictive chromatin structure. Here we explored the use of 5 histone-modifying agents - 4 histone deacetylase inhibitors (HDACi) and 1...

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Hlavní autoři: McDonnel, Samantha J., Sparger, Ellen E., Luciw, Paul A., Murphy, Brian G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513637/
https://ncbi.nlm.nih.gov/pubmed/23073179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2012.10.009
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