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Accelerated Polymer Biodegradation of Risperidone Poly(d, l-Lactide-Co-Glycolide) Microspheres

The influence of a tertiary amine, namely risperidone (pKa = 7.9) on the degradation of poly(d, l lactide-co-glycolide) (PLGA) microspheres was elucidated. Risperidone and blank microspheres were fabricated at two lactide/glycolide ratios, 65:35 and 85:15. The microspheres were characterized for dru...

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Bibliographic Details
Main Authors: Selmin, Francesca, Blasi, Paolo, DeLuca, Patrick P.
Format: Artigo
Language:Inglês
Published: Springer US 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513476/
https://ncbi.nlm.nih.gov/pubmed/23090111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-012-9874-4
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