Osmotically Regulated Floating Asymmetric Membrane Capsule for Controlled Site-Specific Delivery of Ranitidine Hydrochloride: Optimization by Central Composite Design

A nondisintegrating, floating asymmetric membrane capsule (FAMC) was developed to achieve site-specific osmotic flow of a highly water-soluble drug, ranitidine hydrochloride (RHCl), in a controlled manner. Solubility suppression of RHCl was achieved by the common ion effect, using optimized coated s...

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Bibliographic Details
Main Authors: Chauhan, Manvendra S., Kumar, Anil, Pathak, Kamla
Format: Artigo
Language:Inglês
Published: Springer US 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513454/
https://ncbi.nlm.nih.gov/pubmed/23104305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-012-9870-8
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