The epidemiology and treatment of ALS: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials

Effective treatments for amyotrophic lateral sclerosis (ALS) have remained elusive. Only riluzole, a drug thought to affect glutamate metabolism, improves survival albeit to modest extent. Explanations for the negative results of therapeutic trials include a likely heterogeneity, both in disease sus...

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Detalhes bibliográficos
Main Authors: Beghi, Ettore, Chiò, Adriano, Couratier, Philippe, Esteban, Jesùs, Hardiman, Orla, Logroscino, Giancarlo, Millul, Andrea, Mitchell, Douglas, Preux, Pierre-Marie, Pupillo, Elisabetta, Stevic, Zorica, Swingler, Robert, Traynor, Bryan J., Van den Berg, Leonard H., Veldink, Jan H., Zoccolella, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513399/
https://ncbi.nlm.nih.gov/pubmed/20698807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/17482968.2010.502940
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