Evaluation of a phenotypic revertant of the A/Alaska/77-ts-1A2 reassortant virus in hamsters and in seronegative adult volunteers: further evidence that the temperature-sensitive phenotype is responsible for attenuation of ts-1A2 reassortant viruses.

In a previous study, a seronegative child to whom attenuated A/Alaska/77-ts-1A2 virus was administered (37 degrees C shutoff temperature for plaque formation) shed virus with an altered temperature-sensitive (ts) phenotype (40 degrees C shutoff temperature) (Murphy et al., Ann. N.Y. Acad. Sci. 354:1...

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Detalhes bibliográficos
Main Authors: Tolpin, M D, Clements, M L, Levine, M M, Black, R E, Saah, A J, Anthony, W C, Cisneros, L, Chanock, R M, Murphy, B R
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1982
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC351277/
https://ncbi.nlm.nih.gov/pubmed/7085075
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