Increased Neurokinin B (Tac2) Expression in the Mouse Arcuate Nucleus Is an Early Marker of Pubertal Onset with Differential Sensitivity to Sex Steroid-Negative Feedback than Kiss1

At puberty, neurokinin B (NKB) and kisspeptin (Kiss1) may help to amplify GnRH secretion, but their precise roles remain ambiguous. We tested the hypothesis that NKB and Kiss1 are induced as a function of pubertal development, independently of the prevailing sex steroid milieu. We found that levels...

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Autors principals: Gill, John C., Navarro, Víctor M., Kwong, Cecilia, Noel, Sekoni D., Martin, Cecilia, Xu, Shuyun, Clifton, Donald K., Carroll, Rona S., Steiner, Robert A., Kaiser, Ursula B.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
Matèries:
Neuroendocrinology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512019/
https://ncbi.nlm.nih.gov/pubmed/22893725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1529
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