Fetal Glucocorticoid Synthesis Is Required for Development of Fetal Adrenal Medulla and Hypothalamus Feedback Suppression

During pregnancy, fetal glucocorticoid is derived from both maternal supply and fetal secretion. We have created mice with a disruption of the Cyp11a1 gene resulting in loss of fetal steroid secretion but preserving the maternal supply. Cyp11a1null embryos have appreciable although lower amounts of...

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Bibliographische Detailangaben
Hauptverfasser: Huang, Chen-Che Jeff, Shih, Meng-Chun Monica, Hsu, Nai-Chi, Chien, Yu, Chung, Bon-chu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Glucocorticoids-CRH-ACTH-Adrenal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512012/
https://ncbi.nlm.nih.gov/pubmed/22962254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1258
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