Genomic Profiling of a Human Organotypic Model of AEC Syndrome Reveals ZNF750 as an Essential Downstream Target of Mutant TP63

The basis for impaired differentiation in TP63 mutant ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome is unknown. Human epidermis harboring AEC TP63 mutants recapitulated this impairment, along with downregulation of differentiation activators, including HOPX, GRHL3, KLF4, PRDM1, and ZN...

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Détails bibliographiques
Auteurs principaux: Zarnegar, Brian J., Webster, Dan E., Lopez-Pajares, Vanessa, Vander Stoep Hunt, Brook, Qu, Kun, Yan, Karen J., Berk, David R., Sen, George L., Khavari, Paul A.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511987/
https://ncbi.nlm.nih.gov/pubmed/22922031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.07.007
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