Pre-Treatment with Allopurinol or Uricase Attenuates Barrier Dysfunction but Not Inflammation during Murine Ventilator-Induced Lung Injury

INTRODUCTION: Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Ventilator-induced lung injury (VILI) is mediated by the NLRP3 inflammasome and i...

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Main Authors: Kuipers, Maria T., Aslami, Hamid, Vlaar, Alexander P. J., Juffermans, Nicole P., Tuip-de Boer, Anita M., Hegeman, Maria A., Jongsma, Geartsje, Roelofs, Joris J. T. H., van der Poll, Tom, Schultz, Marcus J., Wieland, Catharina W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511544/
https://ncbi.nlm.nih.gov/pubmed/23226314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050559
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