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Gating pore currents and the resting state of Na(v)1.4 voltage sensor domains

Mammalian voltage-gated sodium channels are composed of four homologous voltage sensor domains (VSDs; DI, DII, DIII, and DIV) in which their S4 segments contain a variable number of positively charged residues. We used single histidine (H) substitutions of these charged residues in the Na(v)1.4 chan...

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Detalhes bibliográficos
Main Authors: Gosselin-Badaroudine, Pascal, Delemotte, Lucie, Moreau, Adrien, Klein, Michael L., Chahine, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511134/
https://ncbi.nlm.nih.gov/pubmed/23134726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217990109
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