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Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology
Phallotoxins inhibit the dynamics of microfilaments in cells and lead to apoptosis. Due to poor cellular uptake these effects cannot be studied in live cells, even at millimolar toxin concentrations, nor can phalloidin be used for the elimination of tumor cells. Uptake is greatly enhanced by conjuga...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3511042/ https://ncbi.nlm.nih.gov/pubmed/23209542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.8.233 |
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